From Gene to Function: In Silico Warfare on the West Nile Virus
نویسنده
چکیده
Accelrys European Headquarters 334 Cambridge Science Park Cambridge, CB4 0WN, UK Tel: +44 1223 228500 Accelrys Asia Headquarters Nishi-shimbashi TS Bldg 11F Nishi-shimbashi 3-3-1, Minato-ku, Tokyo, 105-0003, Japan Tel: 81 3 3578 3861 Accelrys Corporate Headquarters 10188 Telesis Court San Diego, CA 92121, USA Tel: +1 858 799 5000 Anne Marie Quinn, Luke Fisher and Dana Haley-Vicente Accelrys Inc., San Diego, CA
منابع مشابه
Aserological survey on antibodies against West Nile virus in horses of Khuzestan province
BACKGROUND: West Nile virus (WNV) is a vector-borneagent that is maintained within a bird-mosquito cycle. In humansand equids, infection by this agent is usually asymptomatic, orcharacterized by a mild febrile illness. However, fatal meningoencephalitisor encephalitis may occur. OBJECTIVES:The aim ofthis study was to evaluate the prevalence of WNVinfection andcorrelation of this organism with h...
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Abstract Background and Objective: West Nile virus (WNV) is a member of the genus Flavivirus that can cause viral infections in human. This study aimed at detecting IgG antibodies against WNV in patients of two cities of Neka and Shiraz. Material and Methods: the participants were 46 possible WNV case from Neka (13 women and 10 men) and Shiraz (10 women and 13 men). IgG assay was ...
متن کاملThe cost-effectiveness of screening the U.S. blood supply for West Nile virus.
BACKGROUND The spread of West Nile virus across North America and evidence of transmission by transfusion prompted the U.S. Food and Drug Administration to encourage the development of methods to screen the blood supply. OBJECTIVE To assess the cost-effectiveness of nucleic acid amplification testing for West Nile virus in the U.S. blood supply. DESIGN Markov cohort simulation. DATA SOURC...
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Viruses of the family Flaviviridae are important human and animal pathogens. Among them, the Flaviviruses dengue (DENV) and West Nile (WNV) cause regular outbreaks with fatal outcomes. The RNA-dependent RNA polymerase (RdRp) activity of the non-structural protein 5 (NS5) is a key activity for viral RNA replication. In this study, crystal structures of enzymatically active and inactive WNV RdRp ...
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The interaction of the mosquito and the invading virus is complex and can result in physiological and gene expression alterations in the insect. The association of West Nile virus (WNV) and Culex pipiens quinquefasciatus mosquitoes results in measurable changes in gene expression; 22 gene products were shown previously to have altered expression. Sequence analysis of one product, CQ G1A1, revea...
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